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Summary
Southern Comfort So Deep In Flavor You Might Start Speaking with a Drawl
This isn’t your typical crockpot meal. We flipped the script to bring you a restaurant level Mississippi Chuck Roast right in your home kitchen. It is deeply savory, boldly tangy, and tender enough to shred with a spoon. The secret? Treating the chuck like a ribeye by drying out the surface moisture and getting an incredible sear. Then following that up with an umami packed bunch of seasonings and letting it slow cook in the oven.
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Additional Details About This Recipe
Can I make this in a slow cooker?
Yes! After searing, transfer everything to a slow cooker and cook on low for 8 hours or high for 4–5 hours.
What can I substitute for pepperoncini?
Pickled banana peppers work well, but avoid sweet varieties—you want tang, not sugar.
Isn’t MSG unhealthly?
It’s all lies! MSG is used like table salt in most asian countries. Even the glorious Chick-fil-a adds it to make their chicken taste heavenly. In all seriousness, much of the health scares that are floating around about MSG were not based on reliable studies. Here is a pretty balanced article on the subject.
Can I freeze this?
Absolutely. Let it cool, then portion into freezer-safe containers with some of the braising liquid.
Can I make it extra spicy?
Yes, swap mild pepperoncini for hot ones and your mouth will be on fire!
Nutritional Facts
Per Serving (1/8 of roast):
- Calories: 385
- Protein: 36g
- Fat: 25g
- Carbohydrates: 4g
- Fiber: 1g
- Sodium: 780mg


